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Regulation of Glucose Homeostasis by GLP1

They had 3 groups and nearly 2500 participants

The effects of exendine-4 on insulin producing cell differentiation from rat bone marrow-derived mesenchymal stem cells

Early researchers noticed that GLP-1 powerfully and appropriately stimulated insulin only when glucose levels were high, meaning it lowered blood sugar without causing dangerous hypoglycemia, says New York internist and longevity expert Amanda Kahn, MD

and Mounjaro (tirzepatide) was approved in May 2022

In a Phase II study published in The New England Journal of Medicine, participants with obesity who received the highest dose of Retatritude (12 mg) experienced an average weight loss of 24.2% over 48 weeks